Welcome to the new world of TMNT! After the cataclysmic events of "City At War," the Turtles find New York City drastically changed–new factions and enemies are on the rise, and allies are in short supply.

Jennika, the newest member of the TMNT team, embarks on her own adventure. Trying to acclimate to life as a mutant, she will be forced to come to terms with both her troubled past and conflicted present. In search of a dangerous procedure to reverse mutation, will Jennika be tempted by the call of her old life, and how far will she go to save those who gave up on her long ago?

Back on the streets, the mutagen bomb's fallout continues to affect NYC in increasingly disturbing ways. As the government struggles to come to grips with a growing humanitarian crisis, mutants start to go missing. The TMNT trace the clues to the waterfront and find something terrifying that is now living in the depths! Meanwhile, a falling out between Baxter and April could have dire consequences for Mutant Town, where life has changed forever.