Continuing from the Webtoons tale—when Zatanna is attacked and bested by a powerful sorceress, her father casts a spell to protect her and send her away from the chaos she's caught in the middle of.

Zatanna arrives in Whitechapel, London, in the year 1888. She soon discovers a serial killer plaguing the streets of the city, Jack the Ripper. Unable to return home and certain that the supernatural killer has answers, Zatanna sets out in pursuit of the Ripper alongside the denizens of Whitechapel and one John Constantine.