A mysterious pandemic causes a quarter of the world to permanently lose the ability to sleep-without any apparent health implications. The outbreak creates a new class of people who are both feared and ostracized, most of whom optimize their extra hours to earn more money.

Journalist Jamie Vega is Sleepless: he can't sleep, nor does he need to. When his boss dies on the eve of a controversial corporate takeover, Jamie doesn't buy the too-convenient explanation of suicide, and launches an investigation of his own.